5 Clinical Trial Myths Debunked: Separating Fact from Fear

Clinical trials are crucial to advancing medicine—yet too many people avoid them because of misinformation. As a physician, I’ve seen firsthand how these myths can prevent patients from accessing potentially life-changing treatment options. Today, let’s unpack some of the most common myths about clinical research, explain what happens during a trial, and help you make […]
May 26, 2025
Dr. Debra Weinstein
Dr. Weinstein is a leading expert in decentralized clinical trials at Science 37, where she has been instrumental in advancing remote research opportunities since 2017. With active medical licensure in 46 states, she oversees a wide range of studies across diverse therapeutic areas, ensuring broader patient access to cutting-edge treatments.

A board-certified internist, Dr. Weinstein has over two decades of experience in clinical research. She has served as a principal investigator on more than 200 trials and has founded multiple research organizations specializing in internal medicine, rheumatology, orthopedics, and pain management. Recognized for her contributions to medical research, she has been named "Woman of the Year" by the National Association of Professional Women.

Clinical trials are crucial to advancing medicine—yet too many people avoid them because of misinformation. As a physician, I’ve seen firsthand how these myths can prevent patients from accessing potentially life-changing treatment options. Today, let’s unpack some of the most common myths about clinical research, explain what happens during a trial, and help you make informed decisions about your care.

Whether you’re living with a chronic condition, navigating limited treatment options, or simply exploring what's available, understanding the truth about clinical trials can open new doors to healing and hope.

Myth #1: “I’ll Be a Guinea Pig”

This is, by far, the most common fear I hear—and it couldn’t be further from the truth.

Fact: Clinical trials are governed by rigorous ethical, scientific, and legal standards. Every trial must receive FDA approval and be reviewed by an Institutional Review Board (IRB)—a committee of doctors, scientists, and community members tasked with protecting your rights and safety. These trials must also comply with strict federal laws that regulate patient safety, informed consent, and transparency. Oversight by federal government agencies like the FDA ensures that clinical research is conducted responsibly and ethically at every stage.

Most people don’t realize that many clinical trials compare a new treatment against the standard of care—what doctors would normally prescribe—so you’re never left untreated. In fact, patients in trials often receive more attention than those in regular care settings, with frequent check-ins, lab tests, and monitoring to ensure your health is prioritized.

A 2022 study published by the NIH found that patients in cancer clinical trials reported higher satisfaction with care than those receiving standard treatments alone, citing better communication and support throughout the process.

Myth #2: “Clinical Trials Are a Last Resort”

Fact: You don’t have to exhaust every option before joining a clinical trial. Many trials are designed for newly diagnosed patients or those already receiving treatment who want access to newer therapies.

Modern clinical trials now span a wide variety of medical conditions, from chronic illnesses like diabetes and depression to rare diseases and preventive health strategies. Some clinical studies test new medications, while others evaluate better ways to deliver care, reduce side effects, or improve quality of life.

With platforms like Science 37, which specialize in decentralized trials, participation is more convenient than ever. You can often complete much of the study from home—via telehealth, mobile nurses, and at-home diagnostics—while still receiving advanced care and supervision from research professionals.

Bonus Tip: Participating in a trial doesn’t mean you’re stuck. You can leave a clinical study at any time, for any reason. That’s part of your informed consent.

Myth #3: “They Won’t Tell Me the Risks”

Fact: Transparency is a cornerstone of ethical clinical research.

Before joining any clinical trial, you’ll be asked to review and sign a consent form that clearly outlines:

  • The purpose of the study
  • The treatment you’ll receive
  • Any known side effects
  • Alternatives to participation
  • Your rights as a participant

Researchers are required to answer every question you have—fully and honestly. They must also update you if new information arises that could affect your decision.

Side effects, of course, are a concern. But remember: every medication or therapy—trial or not—carries potential side effects. In trials, you’re monitored closely, and adverse effects are reported and managed immediately. Your safety isn’t an afterthought—it’s the foundation.

In a 2023/24 clinical research experience survey (completed by over 35,000 participants), most reported a positive experience. 91% of adults and 89% of young people said they’d participate in research again. The majority felt valued, informed, and treated with kindness and respect throughout their participation.

Myth #4: “Clinical Trials Are Too Expensive”

Fact: Clinical trials do not cost you money—in fact, they often reduce your out-of-pocket expenses.

Most trials cover the cost of the clinical research itself, including the study drug, lab work, checkups, and follow-ups. Depending on the trial, you may also be reimbursed for transportation, childcare, or time away from work. Your regular health insurance usually covers routine care unrelated to the study.

Before you enroll, the research team will walk you through what’s covered, what’s not, and help you coordinate with your health care provider if needed. There are no hidden fees or financial obligation to join or stay in a trial.

Did you know? Science 37’s decentralized trials are designed with patient convenience in mind. That means fewer clinic visits, less time away from home, and more support throughout the process—without compromising safety.

Myth #5: “I Won’t Benefit Personally—It’s Just for Science”

Fact: Clinical trial participants often receive cutting-edge treatments years before they’re available to the public.

Some of the most significant medical breakthroughs—like immunotherapy for cancer, mRNA vaccines, and gene therapies—came through patient volunteers who helped bring them to life. But you don’t have to wait for a scientific miracle to see personal benefits.

Many participants report:

  • Faster access to new treatment options
  • Enhanced monitoring of their medical conditions
  • Closer relationships with their care team
  • A sense of purpose knowing they’re helping others

Clinical trials are not just about advancing science—they’re about expanding access. And with modern research studies increasingly focused on diverse and inclusive participation, the aim is to improve outcomes for everyone, not just a select few.

One Science 37 participant shared: “The process was easy, and I felt heard every step of the way. I got better care than before—right from my living room.”

Empowered, Not Afraid

The decision to join a clinical trial should never be made out of fear. It should come from knowledge, clarity, and the support of a trusted care team. At the end of the day, clinical trials are about improving lives—yours included.

If you’re living with a medical condition and wondering if a clinical study might be right for you, it’s worth asking. You deserve every opportunity to feel better, live longer, and receive care tailored to you.

Explore Science 37’s Clinical Trials

At Science 37, we’re redefining clinical trials, putting patient safety, access, and convenience at the heart of everything. Our decentralized trial model allows you to participate wherever you are, with real-time support and care led by licensed medical professionals.

Take the first step today. Explore current studies with Science 37 and discover treatment options that fit your life, not the other way around.

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